The Winter-Baraitser Dysmorphology Database

The Winter-Baraitser Dysmorphology Database (WBDD) currently contains information on nearly 4000 dysmorphic, multiple congenital anomaly and mental retardation syndromes. It includes single gene disorders, sporadic conditions, and those caused by environmental agents.

Although WBDD mainly contains information about non-chromosomal multiple congenital anomaly syndromes, it also includes information about distinctive microdeletion syndromes and those resulting from uniparental disomy. WBDD contains nearly 41000 fully searchable references, linked to the appropriate syndromes.

The Baraitser-Winter Neurogenetics Database

The Baraitser-Winter Neurogenetics Database (BWND) currently contains information on over 3700 syndromes involving the central and peripheral nervous system seen in adults and children. Like the WBDD, it contains information on single gene disorders, sporadic conditions, and those caused by some environmental agents. Many conditions seen by neurologists have only an occasional genetic contribution - such as motor neurone disease - but these have been included. In BWND, search facilities are enhanced by the ability to use age at onset of neurological features, neurological and other clinical features, neuroradiological findings, changes seen on electrophysiological investigation, abnormal biochemistry, and neuropathological findings. BWND contains around 44000 fully searchable references, linked to the appropriate syndromes.

The Photo Library

Now integrated into WBDD and BWND, the Photo Library is a superb collection of 17500 photographs that show the main dysmorphic features of the syndrome and other relevant images, such as skeletal radiographs, hair microscopy, etc. In the case of neurogenetic syndromes, there are CT and MRI images showing their characteristic neuroradiological features, examples of EEG changes or the changes observed on other key electrophysiological investigations and, where relevant, pictures of the characteristic neuropathology, including nerve and muscle biopsy.

The London Ophthalmic Genetics Database (GENEEYE)

The latest addition to the LMD series, GENEEYE is a comprehensive database of over 2500 genetic ophthalmic conditions. Ophthalmological features have been considerably extended and all the syndromes from WBDD and BWND with an eye feature extracted and reclassified according to their features. To this has been added many single congenital anomalies both genetic and sporadic, including all the corneal dystrophies, macular dystrophies, the scores of different rod-cone dystrophies and much else. GENEEYE contains over 34000 fully searchable references, linked to the appropriate syndromes. GENEEYE has been developed with the support and assistance of Hans Møller, Isabelle Russell-Eggitt and David Taylor.